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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AB084281 is the fusion of parental proteins KAT6A, ASXL2 (from a repository: Sun Nov 20 09:24:29 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins19 (35.85 %)
The number (and %) of the tumor suppressors8 (15.09 %)
Total number of binary PPIs (saturation %)192 (13.93 %)
The number (and %) of affected PPIs52 (27.08 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI6.566
Assortativity coefficient-0.3585
The network average Clustering coefficient0.589
The number (and %) of a zero Clustering coefficients5 (9.43 %)
The number (and %) of a zero Betweenness Centrality20 (37.74 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: KAT6A,ASXL2 All fusions
: AB084281;
Proteins found in more fusions RUNX1 (see 1 fusions); CREBBP (see 5 fusions); ATN1 (see 1 fusions); TRAF6 (see 1 fusions); APP (see 4 fusions); EP300 (see 1 fusions); ATXN1 (see 3 fusions); HCFC1 (see 2 fusions); UBC (see 1 fusions); PML (see 4 fusions); KMT2A (see 16 fusions); PRPF40A (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AB084281chimera520.0921936.575DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
PHD (PF00628, IPR019787, SM00249): PHD-finger
HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
zf-C2H2_4 (PF13894): C2H2-type zinc finger
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
ASXH (PF13919, IPR028020): Asx homology domain
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
2 AKT1oncoprotein80.6673.467PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 APPprotein found in more fusions70.6004.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATN1protein found in more fusions41.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
5 ATXN1protein found in more fusions60.4004.500AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 BAP1suppressor80.4649.900Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
7 BRPF1interactor50.5003.833Pap_E4 (PF02711, IPR003861): E4 protein
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
8 CCNB1oncoprotein21.0000Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
9 CREBBPsuppressor160.41938.322Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
10 CRKoncoprotein40.6671.500SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 ELAVL1oncoprotein110.26726.786RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 EP300oncoprotein180.28773.167Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
13 ESR1suppressor120.45521.233Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
14 EXOSC2interactor21.0000EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
KH_6 (PF15985, IPR004088): KH domain
15 FOXK1interactor60.6004.019Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
16 FOXK2interactor80.5367.752FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
17 H3F3Concoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HCFC1protein found in more fusions100.36115.200fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
19 HECW2interactor60.7001.333C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
20 HEMGNinteractor21.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
21 HIST1H3Ainteractor110.40023.122Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
22 HIST1H4Ainteractor50.9000.222CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
23 HIST1H4Ioncoprotein21.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
24 HIST2H3Cinteractor50.5003.056Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
25 HIST3H3interactor60.8670.722Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
26 HIST4H4interactor51.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
27 HSPA4interactor80.46410.386Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
28 ING5suppressor50.6003.167ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
29 KDM1Binteractor50.6002.800Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
SWIRM (PF04433, IPR007526): SWIRM domain
30 KMT2Aoncoprotein130.34830.219AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
31 KRBOX4interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
32 L1TD1interactor100FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
Transposase_22 (PF02994, IPR004244): L1 transposable element
33 MAFKoncoprotein31.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
34 MBD5interactor100MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pap_E4 (PF02711, IPR003861): E4 protein
PWWP (PF00855, IPR000313, SM00293): PWWP domain
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
35 MBD6interactor21.0000MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
RRXRR (PF14239, IPR025938): RRXRR protein
36 MEAF6interactor50.5004.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
NuA4 (PF09340, IPR015418): Histone acetyltransferase subunit NuA4
37 OGTinteractor31.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
38 PHF14interactor100Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
C1_2 (PF03107, IPR004146): C1 domain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
LicD (PF04991, IPR007074): LicD family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Rrp15p (PF07890, IPR012459): Rrp15p
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
39 PMLsuppressor80.4768.500zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
40 PNPLA8interactor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
SMC_ScpB (PF04079, IPR005234): Segregation and condensation complex subunit ScpB
Patatin (PF01734, IPR002641): Patatin-like phospholipase
41 PRPF40Aprotein found in more fusions31.0000FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
42 REREoncoprotein60.5334.967Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
43 RNPS1interactor40.5002.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
44 RPL10suppressor40.5003.000Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
45 RSF1oncoprotein21.0000DDT (PF02791, IPR004022, SM00571): DDT domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PHD (PF00628, IPR019787, SM00249): PHD-finger
UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239)
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
46 RUNX1suppressor80.4765.322Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
47 SYMPKinteractor21.0000HEAT (PF02985, IPR000357): HEAT repeat
DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
Symplekin_C (PF12295, IPR022075): Symplekin tight junction protein C terminal
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
48 TNRC6Binteractor21.0000DUF1421 (PF07223, IPR010820): Protein of unknown function (DUF1421)
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Ago_hook (PF10427, IPR019486): Argonaute hook
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TNRC6-PABC_bdg (PF16608, IPR032226): TNRC6-PABC binding domain
RRM_occluded (PF16842, IPR031766): Occluded RNA-recognition motif
49 TP53suppressor170.30860.556DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
50 TRAF6protein found in more fusions90.5367.400SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
51 UBCprotein found in more fusions100.36119.200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
52 UBE2Uinteractor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
53 WDR5interactor170.32465.941WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ASXL2parental proteinDUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain
ASXH (PF13919, IPR028020): Asx homology domain
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
2 KAT6Aparental proteinBUD22 (PF09073, IPR015158): BUD22
MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
zf-met (PF12874): Zinc-finger of C2H2 type

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