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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AB040942 is the fusion of parental proteins NRSN2, CCDC88C (from a repository: Thu Mar 9 15:07:54 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins8 (61.54 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)28 (35.90 %)
The number (and %) of affected PPIs12 (42.86 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.923
Assortativity coefficient-0.1624
The network average Clustering coefficient0.521
The number (and %) of a zero Clustering coefficients4 (30.77 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CCDC88C,NRSN2 All fusions
: AB040942;
Proteins found in more fusions APP (see 4 fusions); ZDHHC17 (see 2 fusions); ITSN2 (see 1 fusions); WHSC1 (see 1 fusions); MCM7 (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AB040942chimera120.106106.000DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HOOK (PF05622, IPR008636): HOOK protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Neurensin (PF14927): Neurensin
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
2 APPprotein found in more fusions70.33310.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 BAG3oncoprotein40.6671.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 CD1Binteractor100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MLANA (PF14991, IPR029242): Protein melan-A
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
5 GNAI3interactor21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
6 ITSN2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
7 KATNA1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
8 LATS2suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
9 MAPK8oncoprotein31.0000DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
10 MCM7protein found in more fusions40.6671.000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
11 SMURF1interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
12 WHSC1oncoprotein31.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
PWWP (PF00855, IPR000313, SM00293): PWWP domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
SET (PF00856, IPR001214, SM00317): SET domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
13 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CCDC88Cparental proteinDUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HOOK (PF05622, IPR008636): HOOK protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
2 NRSN2parental proteinNeurensin (PF14927): Neurensin

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