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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA873180 is the fusion of parental proteins NPTN, TANGO2 (from a repository: Thu Oct 17 14:13:33 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins3 (27.27 %)
The number (and %) of the tumor suppressors2 (18.18 %)
Total number of binary PPIs (saturation %)18 (32.73 %)
The number (and %) of affected PPIs10 (55.56 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.727
Assortativity coefficient-0.3124
The network average Clustering coefficient0.449
The number (and %) of a zero Clustering coefficients4 (36.36 %)
The number (and %) of a zero Betweenness Centrality7 (63.64 %)


List of the fusions

PPI for parental proteins: TANGO2,NPTN All fusions
: AA873180;
Proteins found in more fusions LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AA873180chimera100.11175.000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
2 ELAVL1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
3 FBXO6interactor30.6671.000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
4 HSPD1suppressor21.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
5 LGALS3oncoprotein31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
6 NDUFV2interactor1002Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
7 NIT2suppressor100CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
8 SLC25A5interactor40.5003.000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
9 SURF2interactor100SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
10 UBXN1interactor200Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
11 VMA21interactor21.0000VMA21 (PF09446, IPR019013): VMA21-like domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADSSinteractorAdenylsucc_synt (PF00709, IPR001114, SM00788): Adenylosuccinate synthetase
2 BPNT1interactorInositol_P (PF00459, IPR000760): Inositol monophosphatase family
3 CATsuppressorCatalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
4 CFL1interactorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
5 DPP3interactorPeptidase_M49 (PF03571): Peptidase family M49
6 G6PDinteractorG6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
7 GAPDHoncoproteinGp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
8 GNPDA1interactorGlucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
9 LCMT1interactorLCM (PF04072, IPR007213): Leucine carboxyl methyltransferase
10 NPTNparental proteinC2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
11 NUTF2interactorNTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
12 PEPDinteractorAMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
13 PNLIPRP2interactorLipase (PF00151, IPR013818): Lipase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
14 PNPOinteractorPyridox_oxidase (PF01243, IPR011576): Pyridoxamine 5'-phosphate oxidase
PNPOx_C (PF10590, IPR019576): Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
15 PPA2interactorPyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
16 PPIFinteractorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
17 PRDX1oncoproteinAhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
18 QDPRinteractoradh_short (PF00106, IPR002198): short chain dehydrogenase
19 SCO2interactorSCO1-SenC (PF02630, IPR003782): SCO1/SenC
20 SH3GL2oncoproteinBAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
21 SOD1interactorSod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
22 TANGO2parental proteinTANGO2 (PF05742, IPR008551): Transport and Golgi organisation 2

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