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Visualization interactions

Cytoscape Web for: AA829758 is the fusion of parental proteins HOOK3 (from a repository: Wed Dec 7 16:52:36 2016)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	16
The number (and %) of the onco-proteins	6 (37.50 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	37 (30.83 %)
The number (and %) of affected PPIs	15 (40.54 %)
The number of possible different fusions	3
PPI diameter	2
PPI radius	1
The average degree of PPI	3.625
Assortativity coefficient	-0.2885
The network average Clustering coefficient	0.580
The number (and %) of a zero Clustering coefficients	4 (25.00 %)
The number (and %) of a zero Betweenness Centrality	10 (62.50 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: HOOK3	All fusions : AA829758;
Proteins found in more fusions	CUL3 (see 1 fusions); HOOK1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AA829758	chimera	15	0.133	164.667	HOOK (PF05622, IPR008636): HOOK protein DUF4710 (PF15828, IPR031667): Domain of unknown function (DUF4710)
2	CCDC8	interactor	2	0	0	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
3	CEP63	interactor	2	1.000	0	DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
4	COMTD1	interactor	1	0	0	FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
5	CUL3	protein found in more fusions	4	0.667	0.667	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
6	FNTB	interactor	2	1.000	0	Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
7	HOOK1	protein found in more fusions	6	0.800	1.333	HOOK (PF05622, IPR008636): HOOK protein
8	HOOK2	interactor	8	0.476	10.000	HOOK (PF05622, IPR008636): HOOK protein
9	IFT57	interactor	1	0	0	IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
10	MRE11A	oncoprotein	3	1.000	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
11	NTRK1	oncoprotein	5	0.500	2.667	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
12	SSX2IP	interactor	3	1.000	0	ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein
13	TNFSF13B	oncoprotein	4	1.000	0	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
14	VPS16	interactor	5	0.700	2.667	Vps16_C (PF04840, IPR006925): Vps16, C-terminal region Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
15	VPS41	interactor	4	1.000	0	Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1 Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2 Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16	ZC4H2	interactor	1	0	0	zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	AKTIP	interactor	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2	FAM160A2	interactor	RAI16-like (PF10257, IPR019384): Retinoic acid induced 16-like protein
3	HOOK3	parental protein	HOOK (PF05622, IPR008636): HOOK protein
4	SCFD1	interactor	Sec1 (PF00995, IPR001619): Sec1 family

B a c k t o T o p ⇑