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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins12 (22.22 %)
The number (and %) of the tumor suppressors11 (20.37 %)
Total number of binary PPIs (saturation %)444 (31.03 %)
The number (and %) of affected PPIs53 (11.94 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI15.444
Assortativity coefficient-0.1322
The network average Clustering coefficient0.663
The number (and %) of a zero Clustering coefficients2 (3.70 %)
The number (and %) of a zero Betweenness Centrality7 (12.96 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MED21 All fusions
: AA662056;
Proteins found in more fusions CREBBP (see 6 fusions); KAT2B (see 1 fusions); VDR (see 2 fusions); HTT (see 1 fusions); POLR2A (see 2 fusions); THRA (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA662056chimera530.2641184.924Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
2 BLOC1S6interactor31.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
3 BRCA1suppressor140.52615.369BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
4 CCNCsuppressor240.77218.014Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
5 CDK7oncoprotein80.6193.583Pkinase (PF00069, IPR000719): Protein kinase domain
6 CDK8interactor300.59960.852Pkinase (PF00069, IPR000719): Protein kinase domain
7 CREBBPsuppressor180.37541.680Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
8 CSNK2A2interactor40.6670.472Pkinase (PF00069, IPR000719): Protein kinase domain
9 ELAVL1oncoprotein120.38223.960RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 ESR1suppressor240.51455.571Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
11 ESR2suppressor160.8483.476zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
12 FBXW7suppressor210.80012.453Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
13 GTF2Binteractor100.4899.758Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
14 GTF2E1interactor90.44414.086DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
15 GTF2F1interactor100.55611.551TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
16 HNF4Asuppressor140.6158.833zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
17 HTTprotein found in more fusions70.5335.833HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
18 KAT2Bprotein found in more fusions70.8001.200Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
19 MAGEB4interactor100MAGE (PF01454, IPR002190): MAGE family
Pap_E4 (PF02711, IPR003861): E4 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
20 MED1interactor320.61349.191Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
21 MED10interactor240.80110.208Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
22 MED12oncoprotein260.72920.034Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
23 MED13oncoprotein230.8387.019Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
24 MED14interactor260.72318.247Med14 (PF08638, IPR013947): Mediator complex subunit MED14
25 MED16interactor270.70724.087WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Med16 (PF11635, IPR021665): Mediator complex subunit 16
26 MED17oncoprotein280.68030.994Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
27 MED19interactor230.8923.573Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
28 MED26interactor220.8615.421Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
29 MED28interactor240.83011.159cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
30 MED29interactor230.8923.573Med29 (PF11568, IPR021018): Mediator complex subunit 29
31 MED30interactor230.82312.820Med30 (PF11315, IPR021019): Mediator complex subunit 30
32 MED4interactor290.60167.099Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
33 MED6interactor280.65347.388Med6 (PF04934, IPR007018): MED6 mediator sub complex component
Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
34 MED7interactor250.68044.918Med7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
35 MED8interactor210.8905.872Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
36 PCBD2interactor50.7001.667Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
37 POLR2Aprotein found in more fusions240.43574.526RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
38 POLR2Ginteractor190.69914.445SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
39 PPARGC1Ainteractor140.60416.201Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
40 RACGAP1interactor21.0000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
41 SKP1oncoprotein80.5713.875Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
42 SREBF1interactor140.7824.039HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
43 SSC5Dinteractor100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
44 TARBP2interactor31.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
45 TCERG1interactor40.6671.000FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
46 THRAsuppressor90.6074.938C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
47 THRBsuppressor41.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
48 TP53suppressor190.37359.495DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
49 TRIM27oncoprotein50.5002.500IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
50 VAV2oncoprotein30.6671.000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
51 VDRsuppressor150.6049.112zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
52 ZC3H13interactor170.9341.315FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
53 ZNF655interactor21.0000Asr (PF06392, IPR009435): Acid shock protein repeat
Chordopox_RPO7 (PF05864, IPR008448): Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
54 ZSCAN1interactor40.6670.667SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Tautomerase_2 (PF14552, IPR004370): Tautomerase enzyme

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GTF2H4interactorTfb2 (PF03849, IPR004598): Transcription factor Tfb2
2 MED11interactorMed11 (PF10280, IPR019404): Mediator complex protein
3 MED18interactorMed18 (PF09637, IPR019095): Med18 protein
4 MED20interactorMed20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
5 MED21parental proteinMed21 (PF11221, IPR021384): Subunit 21 of Mediator complex
6 MED22interactorMed22 (PF06179, IPR009332): Surfeit locus protein 5 subunit 22 of Mediator complex
7 MED23interactorMed23 (PF11573, IPR021629): Mediator complex subunit 23
8 MED24interactorMed24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
9 MED9interactorMed9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
10 SMARCB1suppressorSNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1

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