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Visualization interactions

Cytoscape Web for: AA639921 is the fusion of parental proteins APEH (from a repository: Sun Dec 25 22:31:00 2016)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	32
The number (and %) of the onco-proteins	7 (21.88 %)
The number (and %) of the tumor suppressors	3 (9.38 %)
Total number of binary PPIs (saturation %)	120 (24.19 %)
The number (and %) of affected PPIs	31 (25.83 %)
The number of possible different fusions	4
PPI diameter	2
PPI radius	1
The average degree of PPI	6.688
Assortativity coefficient	-0.3288
The network average Clustering coefficient	0.567
The number (and %) of a zero Clustering coefficients	5 (15.62 %)
The number (and %) of a zero Betweenness Centrality	9 (28.12 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: APEH	All fusions : AA639921;
Proteins found in more fusions	LAMP2 (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AA639921	chimera	31	0.163	549.817	Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2	CAND1	interactor	17	0.358	53.617	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
3	CNOT7	interactor	1	0	0	CAF1 (PF04857, IPR006941): CAF1 family ribonuclease
4	CTTN	oncoprotein	7	0.800	1.200	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5	CYHR1	interactor	7	0.524	7.500	Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6	DNM1L	interactor	5	0.667	0.750	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family AAA_16 (PF13191): AAA ATPase domain
7	GARS	interactor	8	0.536	8.533	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
8	H1FX	interactor	7	0.619	4.833	IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
9	HIST1H1C	oncoprotein	5	0.800	1.000	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
10	IPO7	interactor	5	0.900	0.400	Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Xpo1 (PF08389, IPR013598): Exportin 1-like protein DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730)
11	IST1	interactor	1	0	0	Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
12	JMJD6	interactor	11	0.436	20.267	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
13	KARS	interactor	6	0.800	1.250	tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N) tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
14	LAMP2	protein found in more fusions	2	0	0	Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
15	MOV10	interactor	4	0.833	0.250	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
16	NMI	interactor	7	0.533	5.067	IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
17	NTRK1	oncoprotein	17	0.317	58.533	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
18	NXF1	interactor	4	1.000	0	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
19	PAWR	suppressor	8	0.714	4.367	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
20	PPM1G	interactor	7	0.667	3.483	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PP2C (PF00481, IPR001932): Protein phosphatase 2C DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
21	PREPL	interactor	2	0	0	Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
22	SHBG	oncoprotein	2	0	0	Laminin_G_1 (PF00054, IPR001791): Laminin G domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain
23	SHMT1	interactor	8	0.714	3.300	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
24	SHMT2	interactor	12	0.470	24.750	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
25	SNX6	interactor	5	1.000	0	PX (PF00787, IPR001683, SM00312): PX domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
26	STAT1	suppressor	13	0.485	23.083	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
27	TARS	interactor	5	0.600	3.167	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain TGS (PF02824, IPR004095): TGS domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
28	TBCD	interactor	5	0.700	1.667	HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal HEAT_EZ (PF13513): HEAT-like repeat
29	TOLLIP	interactor	4	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain
30	UBA5	interactor	4	0.667	0.667	Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat ThiF (PF00899, IPR000594): ThiF family
31	USP39	oncoprotein	3	1.000	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
32	ZYX	suppressor	4	0.833	0.500	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) LIM (PF00412, IPR001781, SM00132): LIM domain DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	APEH	parental protein	Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2	CARS	oncoprotein	tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
3	HSPA4L	interactor	HSP70 (PF00012, IPR013126): Hsp70 protein
4	LGALS8	interactor	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
5	PFKL	interactor	PFK (PF00365, IPR000023): Phosphofructokinase
6	PFKM	interactor	PFK (PF00365, IPR000023): Phosphofructokinase
7	SERPINE2	interactor	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
8	VPS26A	interactor	Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26

B a c k t o T o p ⇑

Fusion ID: Protein names:	AA639921
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:	all	affected	independent (normal)	missing	nothing (blank)
Chimeric state:	ordinary fusion	big fusion

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors