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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AA639921 is the fusion of parental proteins APEH (from a repository: Sun Dec 25 22:31:00 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins7 (21.88 %)
The number (and %) of the tumor suppressors3 (9.38 %)
Total number of binary PPIs (saturation %)120 (24.19 %)
The number (and %) of affected PPIs31 (25.83 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI6.688
Assortativity coefficient-0.3288
The network average Clustering coefficient0.567
The number (and %) of a zero Clustering coefficients5 (15.62 %)
The number (and %) of a zero Betweenness Centrality9 (28.12 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: APEH All fusions
: AA639921;
Proteins found in more fusions LAMP2 (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA639921chimera310.163549.817Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2 CAND1interactor170.35853.617Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
3 CNOT7interactor100CAF1 (PF04857, IPR006941): CAF1 family ribonuclease
4 CTTNoncoprotein70.8001.200FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 CYHR1interactor70.5247.500Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 DNM1Linteractor50.6670.750Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
7 GARSinteractor80.5368.533HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
8 H1FXinteractor70.6194.833IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
9 HIST1H1Concoprotein50.8001.000Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
10 IPO7interactor50.9000.400Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730)
11 IST1interactor100Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
12 JMJD6interactor110.43620.267AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
13 KARSinteractor60.8001.250tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
14 LAMP2protein found in more fusions200Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
15 MOV10interactor40.8330.250AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
16 NMIinteractor70.5335.067IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
17 NTRK1oncoprotein170.31758.533I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
18 NXF1interactor41.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
19 PAWRsuppressor80.7144.367ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
20 PPM1Ginteractor70.6673.483Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
21 PREPLinteractor200Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
22 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
23 SHMT1interactor80.7143.300SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
24 SHMT2interactor120.47024.750SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
25 SNX6interactor51.0000PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
26 STAT1suppressor130.48523.083SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
27 TARSinteractor50.6003.167HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
28 TBCDinteractor50.7001.667HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
29 TOLLIPinteractor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
30 UBA5interactor40.6670.667Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
31 USP39oncoprotein31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
32 ZYXsuppressor40.8330.500DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 APEHparental proteinPeptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2 CARSoncoproteintRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
3 HSPA4LinteractorHSP70 (PF00012, IPR013126): Hsp70 protein
4 LGALS8interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
5 PFKLinteractorPFK (PF00365, IPR000023): Phosphofructokinase
6 PFKMinteractorPFK (PF00365, IPR000023): Phosphofructokinase
7 SERPINE2interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
8 VPS26AinteractorVps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26

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