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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA632874 is the fusion of parental proteins SDC2 (from a repository: Wed Dec 7 20:55:19 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins3 (37.50 %)
The number (and %) of the tumor suppressors1 (12.50 %)
Total number of binary PPIs (saturation %)17 (60.71 %)
The number (and %) of affected PPIs7 (41.18 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI3.000
Assortativity coefficient-0.7051
The network average Clustering coefficient0.592
The number (and %) of a zero Clustering coefficients2 (25.00 %)
The number (and %) of a zero Betweenness Centrality6 (75.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SDC2 All fusions
: AA632874;
Proteins found in more fusions EZR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA632874chimera70.23827.000Syndecan (PF01034, IPR027789): Syndecan domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
2 CASKinteractor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
3 ELAVL1oncoprotein60.5005.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 EZRprotein found in more fusions41.0000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
5 PRKCAinteractor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
6 PRKCBsuppressor200C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
7 PRKCGinteractor200C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8 SDCBPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANOS1interactorfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
WAP (PF00095, IPR008197, SM00217): WAP-type (Whey Acidic Protein) 'four-disulfide core'
2 ATXN3interactorJosephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
3 BAG6interactorDUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
4 CBX4oncoproteinChromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
5 CSF2suppressorGM_CSF (PF01109, IPR000773, SM00040): Granulocyte-macrophage colony-stimulating factor
6 CSF2RAinteractorIL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
7 CSNK2A2interactorPkinase (PF00069, IPR000719): Protein kinase domain
8 CYP2C18interactorp450 (PF00067, IPR001128): Cytochrome P450
9 EFNB2interactorEphrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
10 EPB41L1interactor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
11 FGF1oncoproteinFGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
12 FGF2oncoproteinFGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
13 FN1oncoproteinfn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
14 GPR183interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
15 HGFoncoproteinKringle (PF00051, IPR000001): Kringle domain
PAN_1 (PF00024, IPR003014): PAN domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
16 ITPR1interactorIns145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
17 LAMA3interactorLaminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
PPE (PF00823, IPR000030): PPE family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
18 POLR2FinteractorRNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
19 PPP3CCsuppressorMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
20 REG3AoncoproteinLectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
21 SDC2parental proteinGlycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
22 SERPINA1oncoproteinSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
23 SLC18A1interactorMFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
24 SYNCRIPinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
25 TMPOinteractorLEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha

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