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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA622384 is the fusion of parental proteins HOXB13, ACTG2 (from a repository: Thu Nov 10 14:59:26 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins18 (58.06 %)
The number (and %) of the tumor suppressors1 (3.23 %)
Total number of binary PPIs (saturation %)62 (13.33 %)
The number (and %) of affected PPIs30 (48.39 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI2.903
Assortativity coefficient-0.3809
The network average Clustering coefficient0.432
The number (and %) of a zero Clustering coefficients14 (45.16 %)
The number (and %) of a zero Betweenness Centrality23 (74.19 %)


List of the fusions

PPI for parental proteins: HOXB13,ACTG2 All fusions
: AA622384;
Proteins found in more fusions CBL (see 1 fusions); MCM2 (see 1 fusions); KAT5 (see 3 fusions); ERBB3 (see 1 fusions); KCNMA1 (see 2 fusions); LRRK2 (see 1 fusions); ERRFI1 (see 1 fusions); POU2F1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AA622384chimera300.034823.667Actin (PF00022, IPR004000, SM00268): Actin
2 ALX4interactor31.0000OAR (PF03826, IPR003654): OAR domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
3 ARRB2interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4 CBLoncoprotein200Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
5 EEDsuppressor50.5003.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 ELK1oncoprotein200Ets (PF00178, IPR000418, SM00413): Ets-domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
7 EMDinteractor60.6003.667LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
8 ERBB3oncoprotein200Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 ERRFI1oncoprotein200GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
10 FAF2interactor60.6003.667DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
11 FOXA2oncoprotein100Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
HNF_C (PF09354, IPR018533): HNF3 C-terminal domain
TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
12 FOXC2oncoprotein31.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
13 FOXE1oncoprotein21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
14 FOXF1interactor200Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
15 FOXG1oncoprotein100SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
16 FOXRED2interactor21.0000Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
17 FOXS1interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
18 HOXD4interactor100SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
19 IRF4oncoprotein100IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
20 KAT5oncoprotein200MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
21 KCNMA1protein found in more fusions31.0000BK_channel_a (PF03493, IPR003929): Calcium-activated BK potassium channel alpha subunit
Ion_trans (PF00520, IPR005821): Ion transport protein
TrkA_N (PF02254, IPR003148): TrkA-N domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
SUZ (PF12752, IPR024771): SUZ domain
22 LRRK2oncoprotein200Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
23 MCM2oncoprotein50.6672.000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
24 MLH1oncoprotein100DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
25 NEBoncoprotein21.0000Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
DUF3417 (PF11897, IPR024517): Protein of unknown function (DUF3417)
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
NFRKB_winged (PF14465, IPR025220): NFRKB Winged Helix-like
SH3_9 (PF14604, IPR001452): Variant SH3 domain
26 NOP56interactor30.6671.000Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
27 POU2F1protein found in more fusions40.6671.000Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
28 RNF2interactor50.6672.000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
29 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
30 UBL4Ainteractor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 ZNF490interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTG2parental proteinActin (PF00022, IPR004000, SM00268): Actin
2 HOXB13parental proteinHomeobox (PF00046, IPR001356, SM00389): Homeobox domain
HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
3 TEAD2interactorTEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family

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