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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA593360 is the fusion of parental proteins ENC1 (from a repository: Wed Dec 7 06:59:14 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)4
The number (and %) of the onco-proteins4 (100.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)9 (150.00 %)
The number (and %) of affected PPIs3 (33.33 %)
The number of possible different fusions3
PPI diameter1
PPI radius1
The average degree of PPI3.000
Assortativity coefficient0
The network average Clustering coefficient1.000
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality4 (100.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ENC1 All fusions
: AA593360;
Proteins found in more fusions HSP90AA1 (see 2 fusions); CUL3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA593360chimera31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
2 CUL3protein found in more fusions41.0000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
3 HSP90AA1oncoprotein41.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
4 KEAP1oncoprotein41.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTBoncoproteinActin (PF00022, IPR004000, SM00268): Actin
2 ENC1parental proteinBACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
HTH_12 (PF08461, IPR013668): Ribonuclease R winged-helix domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
3 NACC1interactorBTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
4 NFE2L2oncoproteinbZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
5 RB1suppressorRB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
6 RBX1oncoproteinzf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
7 SNCAinteractorSynuclein (PF01387, IPR001058): Synuclein
8 SQSTM1oncoproteinPB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain

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