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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA581184 is the fusion of parental proteins GLUL (from a repository: Tue Dec 6 05:23:53 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins9 (33.33 %)
The number (and %) of the tumor suppressors4 (14.81 %)
Total number of binary PPIs (saturation %)56 (15.95 %)
The number (and %) of affected PPIs26 (46.43 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI3.407
Assortativity coefficient-0.5577
The network average Clustering coefficient0.549
The number (and %) of a zero Clustering coefficients9 (33.33 %)
The number (and %) of a zero Betweenness Centrality21 (77.78 %)


List of the fusions

PPI for parental proteins: GLUL All fusions
: AA581184;
Proteins found in more fusions ZNRF1 (see 1 fusions); PIAS1 (see 2 fusions); MCM2 (see 1 fusions); UBC (see 1 fusions); NFKB1 (see 2 fusions); PIAS2 (see 2 fusions); PPARD (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AA581184chimera260.062578.000Gln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain
Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain
2 ASPSCR1oncoprotein21.0000DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
UBX (PF00789, IPR001012, SM00166): UBX domain
TUG-UBL1 (PF11470, IPR021569): TUG ubiquitin-like domain
3 CASP8AP2interactor41.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
4 CYP39A1interactor100p450 (PF00067, IPR001128): Cytochrome P450
5 DMXL2interactor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Rav1p_C (PF12234, IPR022033): RAVE protein 1 C terminal
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 FAM129Binteractor100PH (PF00169, IPR001849, SM00233): PH domain
7 HIPK1interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
8 HIPK3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
9 HSD17B10interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
10 MCM2oncoprotein40.6671.000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
11 NFKB1suppressor200Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
12 NME7interactor21.0000DUF1126 (PF06565, IPR010554): Repeat of unknown function (DUF1126)
NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
13 NUDT18interactor100NUDIX (PF00293, IPR000086): NUDIX domain
14 PIAS1suppressor70.6004.000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
15 PIAS2protein found in more fusions41.0000SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
16 PIAS3oncoprotein31.0000SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
17 PLEKHF2interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
18 PPARDoncoprotein200zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19 RABEPKinteractor100Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
20 RBBP6oncoprotein31.0000DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DWNN (PF08783, IPR014891): DWNN domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
U-box (PF04564, IPR003613, SM00504): U-box domain
SBF2 (PF12335, IPR022096): Myotubularin protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
PRIMA1 (PF16101): Proline-rich membrane anchor 1
21 SKILsuppressor60.7002.000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
22 TCHPsuppressor21.0000TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
TPH (PF13868): Trichohyalin-plectin-homology domain
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
23 UBAP2interactor100Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
CUE (PF02845, IPR003892, SM00546): CUE domain
HlyE (PF06109, IPR027018): Haemolysin E (HlyE)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2
UBA_4 (PF14555): UBA-like domain
24 UBCprotein found in more fusions60.4006.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 UBE2Iinteractor100.38919.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
26 ZFAND2Binteractor21.0000UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
27 ZNRF1protein found in more fusions31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GLULparental proteinGln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain
Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain
2 MT-ND5interactorNA

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