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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA373754 is the fusion of parental proteins RNF213, SLC16A3 (from a repository: Thu Dec 8 21:15:39 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins9 (32.14 %)
The number (and %) of the tumor suppressors3 (10.71 %)
Total number of binary PPIs (saturation %)48 (12.70 %)
The number (and %) of affected PPIs27 (56.25 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.714
Assortativity coefficient-0.3519
The network average Clustering coefficient0.418
The number (and %) of a zero Clustering coefficients13 (46.43 %)
The number (and %) of a zero Betweenness Centrality21 (75.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RNF213,SLC16A3 All fusions
: AA373754;
Proteins found in more fusions EGFR (see 2 fusions); MCM2 (see 1 fusions); TERF2IP (see 1 fusions); UBC (see 1 fusions); GAN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA373754chimera270.031670.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
PX (PF00787, IPR001683, SM00312): PX domain
RNA_helicase (PF00910, IPR000605): RNA helicase
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DZR (PF12773, IPR025874): Double zinc ribbon
AAA_16 (PF13191): AAA ATPase domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 BANPsuppressor31.0000DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
3 CBX2interactor21.0000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
CBX7_C (PF17218): CBX family C-terminal motif
4 CBX4oncoprotein40.6671.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
5 CBX6interactor21.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
6 CD244interactor100Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
7 DIAPH1interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
8 EGFRoncoprotein40.6671.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 FAM9Binteractor200Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
10 GANprotein found in more fusions200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
11 GOLGA2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
12 IFI16suppressor100HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
13 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
14 MCM2oncoprotein40.6671.000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
15 MRPL50interactor100Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
16 NR2C2APinteractor21.0000F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
17 PLAC9interactor100PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
18 PTPN1suppressor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
19 RELoncoprotein21.0000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
20 RNASEH2Binteractor100RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
21 SCN2Binteractor100DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
22 TERF2IPprotein found in more fusions40.6671.000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
23 TRIM23interactor31.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
24 TRIM27oncoprotein50.5003.000IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
25 TRIP6interactor100DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
26 TSNAXinteractor21.0000Translin (PF01997, IPR002848): Translin family
27 UBCprotein found in more fusions50.5003.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
28 UBXN11interactor100DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 RNF213parental proteinAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NOB1_Zn_bind (PF08772, IPR014881): Nin one binding (NOB1) Zn-ribbon like
PX (PF00787, IPR001683, SM00312): PX domain
RNA_helicase (PF00910, IPR000605): RNA helicase
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
AAA_16 (PF13191): AAA ATPase domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Nudix_N_2 (PF14803, IPR029401): Nudix N-terminal
2 SLC16A3parental proteinMFS_1 (PF07690, IPR011701): Major Facilitator Superfamily

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