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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA361293 is the fusion of parental proteins LONP2 (from a repository: Thu Feb 9 00:45:53 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins4 (50.00 %)
The number (and %) of the tumor suppressors2 (25.00 %)
Total number of binary PPIs (saturation %)14 (50.00 %)
The number (and %) of affected PPIs7 (50.00 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.500
Assortativity coefficient-0.4629
The network average Clustering coefficient0.435
The number (and %) of a zero Clustering coefficients3 (37.50 %)
The number (and %) of a zero Betweenness Centrality5 (62.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SIAH1,LONP2 All fusions
: AA361293;
Proteins found in more fusions OS9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA361293chimera70.14334.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
2 AMOToncoprotein31.0000FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
3 DCNsuppressor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
4 ELAVL1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 FBXW11interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 OS9protein found in more fusions200DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
7 PEX5interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
8 WWOXsuppressor30.6671.000adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 IL17AsuppressorIL17 (PF06083, IPR010345): Interleukin-17
2 LONP2parental proteinAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
Phage_CP76 (PF06892, IPR009679): Phage regulatory protein CII (CP76)
Sld5 (PF05916, IPR021151): GINS complex protein
TIP49 (PF06068, IPR010339): TIP49 C-terminus
3 RSPH9interactorRadial_spoke (PF04712, IPR006802): Radial spokehead-like protein

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