Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	125
The number (and %) of the onco-proteins	34 (27.20 %)
The number (and %) of the tumor suppressors	11 (8.80 %)
Total number of binary PPIs (saturation %)	599 (7.73 %)
The number (and %) of affected PPIs	124 (20.70 %)
The number of possible different fusions	16
PPI diameter	2
PPI radius	1
The average degree of PPI	8.672
Assortativity coefficient	-0.2975
The network average Clustering coefficient	0.402
The number (and %) of a zero Clustering coefficients	10 (8.00 %)
The number (and %) of a zero Betweenness Centrality	21 (16.80 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TLE5	All fusions : AA356820;
Proteins found in more fusions	GFAP (see 3 fusions); U2AF2 (see 2 fusions); MLX (see 1 fusions); BCL6 (see 2 fusions); TRIM26 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); MAPK14 (see 1 fusions); RBPMS (see 2 fusions); RUNX1 (see 1 fusions); SOX5 (see 1 fusions); TMCC2 (see 3 fusions); ATN1 (see 1 fusions); FOXP2 (see 2 fusions); SMAD3 (see 3 fusions);

List of the fusions

PPI for parental proteins: TLE5

All fusions

: AA356820;

Proteins found in more fusions

GFAP (see 3 fusions); U2AF2 (see 2 fusions); MLX (see 1 fusions); BCL6 (see 2 fusions); TRIM26 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); MAPK14 (see 1 fusions); RBPMS (see 2 fusions); RUNX1 (see 1 fusions); SOX5 (see 1 fusions); TMCC2 (see 3 fusions); ATN1 (see 1 fusions); FOXP2 (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AA356820	chimera	124	0.055	12011.361	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
2	ABI2	suppressor	16	0.238	61.538	Abi_HHR (PF07815, IPR012849): Abl-interactor HHR NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region SH3_9 (PF14604, IPR001452): Variant SH3 domain TMEM171 (PF15471, IPR029173): Transmembrane protein family 171 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3	AR	oncoprotein	6	0.700	1.833	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4	ARHGAP32	oncoprotein	3	0.667	0.400	PX (PF00787, IPR001683, SM00312): PX domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RPEL (PF02755, IPR004018, SM00707): RPEL repeat SH3_9 (PF14604, IPR001452): Variant SH3 domain
5	ATN1	protein found in more fusions	9	0.286	18.000	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
6	BCL6	oncoprotein	6	0.400	4.900	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
7	BHLHE40	interactor	6	0.800	0.833	Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
8	BIRC7	interactor	4	0.667	0.333	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9	BYSL	interactor	11	0.200	24.220	Bystin (PF05291, IPR007955): Bystin MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
10	C1orf216	interactor	7	0.286	8.718	DUF4653 (PF15546, IPR027812): Domain of unknown function (DUF4653)
11	C1orf94	interactor	12	0.218	32.400	DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
12	CALCOCO2	interactor	13	0.212	28.919	bZIP_1 (PF00170, IPR004827): bZIP transcription factor CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding zf-C2H2_4 (PF13894): C2H2-type zinc finger
13	CAPN1	interactor	1	0	0	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
14	CARD9	interactor	10	0.389	13.465	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper IncA (PF04156, IPR007285): IncA protein NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
15	CCDC57	interactor	6	0.400	3.905	CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) Fez1 (PF06818): Fez1 Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 SlyX (PF04102, IPR007236): SlyX Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF3983 (PF13137, IPR025041): Protein of unknown function (DUF3983) GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
16	CCNJL	interactor	5	0.400	4.233	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
17	CCNK	interactor	8	0.393	12.900	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
18	CFAP206	interactor	8	0.286	9.482	THP2 (PF09432, IPR018557): Tho complex subunit THP2 DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
19	CPSF7	interactor	4	0.500	2.000	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
20	CRACR2A	interactor	3	0.667	1.000	Ras (PF00071, IPR001806, SM00173): Ras family TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
21	CRX	interactor	5	0.400	4.233	TF_Otx (PF03529, IPR013851): Otx1 transcription factor Homeobox (PF00046, IPR001356, SM00389): Homeobox domain SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
22	DDX6	oncoprotein	11	0.200	26.596	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23	DIP2A	interactor	2	1.000	0	AMP-binding (PF00501, IPR000873): AMP-binding enzyme Cornifin (PF02389, IPR003302): Cornifin (SPRR) family DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
24	EAF1	suppressor	3	1.000	0	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Peroxin-3 (PF04882, IPR006966): Peroxin-3 EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
25	ELAVL1	oncoprotein	16	0.181	77.967	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26	FAM124A	interactor	5	0.500	5.000	FAM124 (PF15067, IPR029380): FAM124 family
27	FAM124B	interactor	12	0.303	25.278	FAM124 (PF15067, IPR029380): FAM124 family
28	FBF1	interactor	16	0.175	70.191	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family YlqD (PF11068, IPR021297): YlqD protein KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
29	FOXP2	protein found in more fusions	4	0.667	1.000	Auxin_repressed (PF05564, IPR008406): Dormancy/auxin associated protein CDC45 (PF02724, IPR003874): CDC45-like protein Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein Forkhead (PF00250, IPR001766, SM00339): Forkhead domain Draxin (PF15550, IPR029094): Draxin SPATA3 (PF15662, IPR026717): Spermatogenesis-associated protein 3 family FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
30	FSD2	interactor	1	0	0	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain REJ (PF02010, IPR002859): REJ domain SPRY (PF00622, IPR003877, SM00449): SPRY domain BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 PRY (PF13765, IPR006574, SM00589): SPRY-associated domain IZUMO (PF15005, IPR029389): Izumo sperm-egg fusion, Ig domain-associated Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
31	GFAP	protein found in more fusions	11	0.356	21.019	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
32	GFI1B	oncoprotein	5	0.500	3.667	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
33	GOLGA2	interactor	22	0.134	120.676	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
34	GORASP2	interactor	9	0.333	17.756	GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
35	GRB2	oncoprotein	15	0.264	51.167	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
36	GTF2E1	interactor	3	0.667	0.500	DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980) TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
37	HGH1	interactor	3	0.667	0.667	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383) DUF384 (PF04064, IPR007206): Domain of unknown function (DUF384)
38	HGS	interactor	14	0.220	57.532	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
39	HMGB1	oncoprotein	6	0.467	7.000	HMG_box_2 (PF09011, IPR009071): HMG-box domain NOA36 (PF06524, IPR010531): NOA36 protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
40	HNF1A	oncoprotein	4	0.667	1.000	HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
41	HNRNPAB	interactor	3	0.667	0.667	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain GRP (PF07172, IPR010800): Glycine rich protein family NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
42	HNRNPF	interactor	7	0.333	11.400	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
43	HOMEZ	interactor	5	0.500	2.533	Homeobox_KN (PF05920, IPR008422): Homeobox KN domain Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez WRNPLPNID (PF15017): Putative WW-binding domain and destruction box PRIMA1 (PF16101): Proline-rich membrane anchor 1
44	IKZF3	suppressor	16	0.162	56.424	C1_2 (PF03107, IPR004146): C1 domain Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2H2_7 (PF15269): Zinc-finger
45	KANK2	interactor	7	0.533	4.419	KN_motif (PF12075, IPR021939): KN motif Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
46	KIFC3	oncoprotein	17	0.233	71.303	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
47	KRT13	interactor	5	0.400	3.033	Filament (PF00038, IPR001664): Intermediate filament protein FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus Keratin_2_head (PF16208, IPR032444): Keratin type II head
48	KRT15	interactor	13	0.308	34.405	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
49	KRT31	interactor	15	0.181	52.919	Filament (PF00038, IPR001664): Intermediate filament protein
50	KRT40	interactor	22	0.126	119.238	Filament (PF00038, IPR001664): Intermediate filament protein UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
51	KRTAP10-3	interactor	17	0.392	36.467	Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
52	KRTAP10-7	interactor	13	0.530	13.660	Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein PMG (PF05287, IPR007951): PMG protein DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106) Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
53	KRTAP10-8	interactor	13	0.530	18.426	Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein PMG (PF05287, IPR007951): PMG protein Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
54	KRTAP10-9	interactor	12	0.618	11.460	Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
55	L3MBTL2	interactor	1	0	0	MBT (PF02820, IPR004092, SM00561): mbt repeat
56	LDOC1	oncoprotein	10	0.333	14.276	DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
57	LMO1	oncoprotein	10	0.244	17.841	LIM (PF00412, IPR001781, SM00132): LIM domain Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
58	LMO2	oncoprotein	19	0.196	81.474	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal LIM (PF00412, IPR001781, SM00132): LIM domain
59	LMO4	interactor	10	0.222	18.033	LIM (PF00412, IPR001781, SM00132): LIM domain zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
60	MAGOHB	interactor	7	0.286	4.327	Mago_nashi (PF02792, IPR004023): Mago nashi protein
61	MAPK14	oncoprotein	4	0.667	0.667	Pkinase (PF00069, IPR000719): Protein kinase domain
62	MBNL1	interactor	2	1.000	0	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 (PF15663): Zinc-finger containing family
63	MED31	interactor	3	0.667	0.667	Med31 (PF05669, IPR008831): SOH1
64	MFAP1	interactor	9	0.333	13.986	MFAP1 (PF06991, IPR009730): Microfibril-associated/Pre-mRNA processing DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464) SIR4_SID (PF16991, IPR031556): Sir4 SID domain
65	MIA2	suppressor	2	1.000	0	NESP55 (PF06390, IPR009434): Neuroendocrine-specific golgi protein P55 (NESP55) SH3_2 (PF07653, IPR011511): Variant SH3 domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
66	MLX	protein found in more fusions	2	0	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3322 (PF11795, IPR024537): Uncharacterized protein conserved in bacteria N-term (DUF3322)
67	MOV10	interactor	11	0.218	38.700	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
68	MTUS2	suppressor	10	0.222	13.067	DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496) RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat FAM184 (PF15665): Family with sequence similarity 184, A and B
69	MVP	oncoprotein	15	0.198	49.594	Vault (PF01505, IPR002499): Major Vault Protein repeat DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543) MVP_shoulder (PF11978, IPR021870): Shoulder domain
70	MYO15B	interactor	2	1.000	0	FERM_M (PF00373, IPR019748): FERM central domain MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_9 (PF14604, IPR001452): Variant SH3 domain BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
71	NAB2	oncoprotein	8	0.571	5.283	NCD1 (PF04904, IPR006988): NAB conserved region 1 (NCD1) NCD2 (PF04905, IPR006989): NAB conserved region 2 (NCD2)
72	NCDN	interactor	1	0	0	Neurochondrin (PF05536, IPR008709): Neurochondrin
73	NEK6	interactor	7	0.333	3.084	Pkinase (PF00069, IPR000719): Protein kinase domain
74	NOTCH2NL	interactor	17	0.353	56.802	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
75	OLIG3	interactor	3	0.667	1.000	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
76	OSGIN1	suppressor	5	0.400	2.583	Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
77	PARVG	interactor	2	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
78	PPP1R16A	interactor	3	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
79	PRKAA1	suppressor	17	0.191	79.588	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
80	PRKAA2	suppressor	12	0.318	28.633	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
81	PRPF31	interactor	17	0.192	60.243	Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
82	PRR3	interactor	3	0.667	1.000	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
83	PTRH2	interactor	1	0	0	PTH2 (PF01981, IPR002833): Peptidyl-tRNA hydrolase PTH2
84	QARS	interactor	4	0.500	2.000	tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
85	RBM10	interactor	7	0.400	7.667	G-patch (PF01585, IPR000467, SM00443): G-patch domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site zf-C2H2_4 (PF13894): C2H2-type zinc finger DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337) FAM176 (PF14851): FAM176 family
86	RBPMS	protein found in more fusions	15	0.231	50.186	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
87	REL	oncoprotein	14	0.176	52.993	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
88	RELA	oncoprotein	10	0.389	17.750	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
89	RFX6	interactor	6	0.400	5.367	RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
90	RHOXF2	interactor	8	0.524	7.119	DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367) GRP (PF07172, IPR010800): Glycine rich protein family Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
91	RIMBP3	interactor	3	0.667	0.400	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SH3_2 (PF07653, IPR011511): Variant SH3 domain tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain G-gamma (PF00631, IPR015898, SM00224): GGL domain Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
92	RNF31	interactor	8	0.381	11.833	Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain PUB (PF09409, IPR018997): PUB domain TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
93	RUNX1	suppressor	5	0.500	2.333	Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
94	SCNM1	interactor	12	0.379	26.636	zf-SCNM1 (PF15803, IPR031622): Zinc-finger of sodium channel modifier 1 SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
95	SDCBP	interactor	15	0.181	63.669	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
96	SH3GL3	interactor	2	0	0	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
97	SIX1	oncoprotein	1	0	0	KilA-N (PF04383, IPR018004): KilA-N domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
98	SIX3	interactor	2	1.000	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
99	SIX6	interactor	2	1.000	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain FAM199X (PF15814, IPR029672): Protein family FAM199X SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
100	SKIL	suppressor	5	0.500	1.952	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
101	SMAD3	oncoprotein	11	0.222	31.667	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
102	SNRPC	interactor	9	0.250	20.752	zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
103	SOX5	oncoprotein	6	0.400	3.352	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOAR (PF16533, IPR032393): STIM1 Orai1-activating region MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
104	SRPK2	oncoprotein	10	0.222	22.967	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
105	STK16	interactor	16	0.238	53.536	Pkinase (PF00069, IPR000719): Protein kinase domain
106	STX11	interactor	10	0.278	19.955	KxDL (PF10241, IPR019371): Uncharacterized conserved protein Syntaxin (PF00804, IPR006011, SM00503): Syntaxin SNARE (PF05739, IPR000727, SM00397): SNARE domain
107	STYXL1	interactor	1	0	0	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
108	TBX3	oncoprotein	3	1.000	0	T-box (PF00907, IPR001699, SM00425): T-box TBX (PF12598, IPR022582): T-box transcription factor
109	TCF4	suppressor	17	0.132	82.119	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
110	TLE1	interactor	9	0.321	18.333	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
111	TLE3	interactor	2	0	0	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
112	TMCC2	protein found in more fusions	8	0.333	10.652	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
113	TRAF1	oncoprotein	11	0.289	26.967	HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
114	TRAF2	interactor	13	0.258	40.852	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
115	TRIM26	protein found in more fusions	4	0.667	1.000	Nop14 (PF04147, IPR007276): Nop14-like family SPRY (PF00622, IPR003877, SM00449): SPRY domain IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57 zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
116	TRIM27	oncoprotein	19	0.163	73.605	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
117	TRIM41	interactor	8	0.381	12.667	BUD22 (PF09073, IPR015158): BUD22 Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family RecR (PF02132, IPR023628): RecR protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631) zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
118	TSC22D4	interactor	10	0.356	21.252	AflR (PF08493, IPR013700): Aflatoxin regulatory protein TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
119	TSGA10	interactor	5	0.500	1.238	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Pox_A3L (PF05288, IPR007952): Poxvirus A3L Protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
120	TSSK3	interactor	5	0.400	1.556	Pkinase (PF00069, IPR000719): Protein kinase domain
121	U2AF2	protein found in more fusions	11	0.244	29.167	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
122	UBXN11	interactor	6	0.400	6.167	DivIC (PF04977, IPR007060): Septum formation initiator SEP (PF08059, IPR012989, SM00553): SEP domain UBX (PF00789, IPR001012, SM00166): UBX domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
123	ZBTB24	interactor	10	0.378	19.550	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zinc_ribbon_4 (PF13717): zinc-ribbon domain
124	ZGPAT	interactor	9	0.389	9.852	Agenet (PF05641, IPR008395, SM00743): Agenet domain G-patch (PF01585, IPR000467, SM00443): G-patch domain Laminin_I (PF06008, IPR009254): Laminin Domain I zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
125	ZNF576	interactor	2	1.000	0	Opy2 (PF09463, IPR018571): Opy2 protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	AEN	interactor	RNase_T (PF00929, IPR013520): Exonuclease
2	AES	parental protein	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3	ATXN1L	interactor	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
4	BAHD1	interactor	BAH (PF01426, IPR001025, SM00439): BAH domain
5	C1orf109	interactor	CK2S (PF15011, IPR029159): Casein Kinase 2 substrate
6	CIB3	interactor	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
7	DGCR6	interactor	DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
8	DNMT3L	interactor	CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
9	EIF4E2	interactor	IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
10	FGFR1OP	oncoprotein	FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
11	FRS3	suppressor	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
12	LINC00526	interactor	NA
13	LSM2	interactor	LSM (PF01423, IPR001163): LSM domain
14	MED4	interactor	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
15	MORF4L2	interactor	MRG (PF05712, IPR026541): MRG
16	NUDT22	interactor	NA
17	VPS37B	interactor	Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
18	VPS37C	interactor	Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein

B a c k t o T o p ⇑

Fusion ID: Protein names:	AA356820
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List of the fusions

List of active interactors

List of missing interactors