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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AA348328 is the fusion of parental proteins PLP1, PRRG1 (from a repository: Mon Jun 5 22:04:04 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins3 (37.50 %)
The number (and %) of the tumor suppressors1 (12.50 %)
Total number of binary PPIs (saturation %)10 (35.71 %)
The number (and %) of affected PPIs7 (70.00 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4880
The network average Clustering coefficient0.256
The number (and %) of a zero Clustering coefficients5 (62.50 %)
The number (and %) of a zero Betweenness Centrality7 (87.50 %)


List of the fusions

PPI for parental proteins: PRRG1,PLP1 All fusions
: AA348328;
Proteins found in more fusions CALR (see 6 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AA348328chimera70.04840.000Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
2 AKT1oncoprotein200PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 CALRoncoprotein200Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
4 CLN8interactor21.0000TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
5 ITGAVsuppressor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Collectrin (PF16959, IPR031588): Renal amino acid transporter
6 ITGB5interactor100EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
7 MBPinteractor100Myelin_MBP (PF01669, IPR000548): Myelin basic protein
8 PTPRNinteractor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
Receptor_IA-2 (PF11548, IPR021613): Protein-tyrosine phosphatase receptor IA-2
RESP18 (PF14948, IPR029403): RESP18 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 FBXO25suppressorElongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
3 NEDD4suppressorRota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
4 NEDD4LsuppressorWW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
5 PLP1parental proteinMyelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
6 PRRG1parental proteinGla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
RCR (PF12273, IPR020999): Chitin synthesis regulation, resistance to Congo red
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family

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