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Visualization interactions

Cytoscape Web for: AA313889 is the fusion of parental proteins TLK1 (from a repository: Thu Nov 10 14:59:26 2016)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	16
The number (and %) of the onco-proteins	7 (43.75 %)
The number (and %) of the tumor suppressors	1 (6.25 %)
Total number of binary PPIs (saturation %)	32 (26.67 %)
The number (and %) of affected PPIs	15 (46.88 %)
The number of possible different fusions	2
PPI diameter	2
PPI radius	1
The average degree of PPI	3.250
Assortativity coefficient	-0.6408
The network average Clustering coefficient	0.530
The number (and %) of a zero Clustering coefficients	5 (31.25 %)
The number (and %) of a zero Betweenness Centrality	11 (68.75 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: TLK1	All fusions : AA313889;
Proteins found in more fusions	UBE3C (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AA313889	chimera	15	0.105	169.667	Pkinase (PF00069, IPR000719): Protein kinase domain Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
2	ASF1A	interactor	3	1.000	0	ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
3	ASF1B	interactor	4	0.833	0.667	ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
4	AURKA	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
5	CHEK1	tumor suppressor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain
6	DYNLL1	interactor	5	0.667	2.000	Dynein_light (PF01221, IPR001372): Dynein light chain type 1
7	ELAVL1	oncoprotein	5	0.500	3.000	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8	INPP1	interactor	2	1.000	0	Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
9	LUZP4	interactor	2	0	0	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
10	MBP	interactor	1	0	0	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
11	NBN	oncoprotein	1	0	0	FHA (PF00498, IPR000253, SM00240): FHA domain Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1 NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
12	TLK2	interactor	7	0.381	12.667	IncA (PF04156, IPR007285): IncA protein Phage_1_1 (PF08200, IPR013232): Bacteriophage 1.1 Protein Pkinase (PF00069, IPR000719): Protein kinase domain Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
13	TPM3	oncoprotein	3	1.000	0	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
14	UBE3C	protein found in more fusions	3	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
15	XPO7	interactor	2	1.000	0	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
16	YWHAE	oncoprotein	1	0	0	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	TLK1	parental protein	Pkinase (PF00069, IPR000719): Protein kinase domain Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term

B a c k t o T o p ⇑