Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AA313889 is the fusion of parental proteins TLK1 (from a repository: Thu Nov 10 14:59:26 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins7 (43.75 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)32 (26.67 %)
The number (and %) of affected PPIs15 (46.88 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI3.250
Assortativity coefficient-0.6408
The network average Clustering coefficient0.530
The number (and %) of a zero Clustering coefficients5 (31.25 %)
The number (and %) of a zero Betweenness Centrality11 (68.75 %)


List of the fusions

PPI for parental proteins: TLK1 All fusions
: AA313889;
Proteins found in more fusions UBE3C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AA313889chimera150.105169.667Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
2 ASF1Ainteractor31.0000ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
3 ASF1Binteractor40.8330.667ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
4 AURKAoncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
5 CHEK1tumor suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
6 DYNLL1interactor50.6672.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
7 ELAVL1oncoprotein50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 INPP1interactor21.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
9 LUZP4interactor200Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
10 MBPinteractor100Myelin_MBP (PF01669, IPR000548): Myelin basic protein
11 NBNoncoprotein100FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
12 TLK2interactor70.38112.667IncA (PF04156, IPR007285): IncA protein
Phage_1_1 (PF08200, IPR013232): Bacteriophage 1.1 Protein
Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
13 TPM3oncoprotein31.0000Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
14 UBE3Cprotein found in more fusions31.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
15 XPO7interactor21.0000IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
16 YWHAEoncoprotein10014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑

List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 TLK1parental proteinPkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term

B a c k    t o    T o p ⇑