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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins13 (34.21 %)
The number (and %) of the tumor suppressors8 (21.05 %)
Total number of binary PPIs (saturation %)144 (20.48 %)
The number (and %) of affected PPIs37 (25.69 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI6.789
Assortativity coefficient-0.4114
The network average Clustering coefficient0.664
The number (and %) of a zero Clustering coefficients2 (5.26 %)
The number (and %) of a zero Betweenness Centrality14 (36.84 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: KAT8 All fusions
: AA159555;
Proteins found in more fusions HCFC1 (see 2 fusions); PRKDC (see 3 fusions); KMT2A (see 16 fusions); YWHAZ (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA159555chimera370.138865.494MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
SCRL (PF06876, IPR010682): Plant self-incompatibility response (SCRL) protein
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
2 ATMsuppressor51.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
3 BAZ2Ainteractor21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DDHD (PF02862, IPR004177, SM01127): DDHD domain
DDT (PF02791, IPR004022, SM00571): DDT domain
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
4 BRD4oncoprotein60.8001.667Caldesmon (PF02029, IPR006018): Caldesmon
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Stm1_N (PF09598, IPR019084): Stm1
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
5 CCAR2suppressor50.5004.000DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DBC1 (PF14443, IPR025954, SM01122): DBC1
S1-like (PF14444, IPR025223): S1-like
6 DYRK1Boncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
7 FOXP3suppressor31.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
8 H2AFXsuppressor100.6009.541Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
9 HCFC1protein found in more fusions70.6674.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
10 HECW2interactor51.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
11 HIST1H2BGoncoprotein40.6670.900Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HIST1H3Ainteractor150.36338.900Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HIST1H4Ainteractor110.45519.719CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
14 HNRNPA1interactor90.6077.800RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
15 KANSL1interactor31.0000PEHE (PF15275, IPR029332): PEHE domain
16 KMT2Aoncoprotein120.40024.908AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
17 MCRS1interactor100FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
18 MORF4L1interactor31.0000MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
19 MSL1interactor70.5716.952Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
PEHE (PF15275, IPR029332): PEHE domain
MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
20 MSL2interactor80.5717.186MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
21 MSL3interactor90.47214.019GET2 (PF08690, IPR028143): GET complex subunit GET2
MRG (PF05712, IPR026541): MRG
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
22 OGTinteractor31.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
23 PAF1oncoprotein60.7331.686Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
24 PHF20oncoprotein40.6670.508GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776)
25 PHF20L1interactor100MBT (PF02820, IPR004092, SM00561): mbt repeat
PHD (PF00628, IPR019787, SM00249): PHD-finger
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PEHE (PF15275, IPR029332): PEHE domain
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
26 PLK1suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
27 PPP1CBinteractor40.8330.667Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
28 PRKDCprotein found in more fusions90.50010.956FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
29 RBBP5oncoprotein80.5717.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30 RNF2interactor80.6674.067zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
31 SIRT1suppressor70.4676.222DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
32 TCEB3suppressor31.0000Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
33 TNK2interactor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
34 TP53suppressor180.27280.100DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
35 TPRoncoprotein21.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
36 WDR5interactor90.50013.056WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
37 YWHAEoncoprotein100.6009.32714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
38 YWHAZprotein found in more fusions110.6009.32714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 KAT8parental proteinMOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
2 MSL3P1interactorNA

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