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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)219
The number (and %) of the onco-proteins66 (30.14 %)
The number (and %) of the tumor suppressors37 (16.89 %)
Total number of binary PPIs (saturation %)1494 (6.26 %)
The number (and %) of affected PPIs218 (14.59 %)
The number of possible different fusions48
PPI diameter2
PPI radius1
The average degree of PPI12.749
Assortativity coefficient-0.2461
The network average Clustering coefficient0.454
The number (and %) of a zero Clustering coefficients18 (8.22 %)
The number (and %) of a zero Betweenness Centrality39 (17.81 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SQSTM1 All fusions
: AA071142;
Proteins found in more fusions PSMC2 (see 1 fusions); MAPK1 (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); PRKCD (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); OPTN (see 1 fusions); LGALS3 (see 2 fusions); ULK1 (see 2 fusions); RARA (see 4 fusions); YWHAZ (see 1 fusions); PIK3R1 (see 1 fusions); SKI (see 1 fusions); HTT (see 1 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); TP53 (see 3 fusions); TRAF6 (see 1 fusions); RARA/PML (see 21 fusions); CHMP2B (see 1 fusions); TKT (see 5 fusions); ENC1 (see 1 fusions); GABARAP (see 2 fusions); LCK (see 1 fusions); LDHA/SKI (see 3 fusions); MAPK14 (see 1 fusions); EEF1D (see 3 fusions); MAPT (see 1 fusions); NDUFS3 (see 1 fusions); MALT1 (see 1 fusions); RARA/NPM1 (see 1 fusions); BAG3 (see 4 fusions); RIPK1 (see 1 fusions); STUB1 (see 1 fusions); HSPB1 (see 4 fusions); CSNK2A1 (see 1 fusions); EPAS1 (see 1 fusions); DAZAP2 (see 2 fusions); CDC37 (see 2 fusions); TGM2 (see 4 fusions); PML (see 4 fusions); RPTOR (see 3 fusions); MEIS2 (see 1 fusions); SMAD3 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AA071142chimera2180.05033801.455PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
2 ABHD10interactor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3 AGAP1interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Pap_E4 (PF02711, IPR003861): E4 protein
PH (PF00169, IPR001849, SM00233): PH domain
Ras (PF00071, IPR001806, SM00173): Ras family
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
4 AJUBAoncoprotein80.3579.859LIM (PF00412, IPR001781, SM00132): LIM domain
5 AKT1S1interactor60.9000.250Pap_E4 (PF02711, IPR003861): E4 protein
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
6 ARHGEF28interactor31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
7 ASPHinteractor31.0000Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
Asp_Arg_Hydrox (PF05118, IPR007803): Aspartyl/Asparaginyl beta-hydroxylase
LUC7 (PF03194, IPR004882): LUC7 N_terminus
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
8 ATG4Binteractor100.5335.717Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
9 ATG7interactor100.42211.921ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
10 ATXN3interactor140.37228.719Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11 BAG3oncoprotein300.180208.952BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
12 BCL10suppressor100.41713.187CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
13 BCL2oncoprotein150.37432.639Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
14 BIDoncoprotein100.41714.591BID (PF06393, IPR010479): BH3 interacting domain (BID)
15 BLOC1S5interactor21.0000Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
16 BNIP1interactor21.0000DUF1537 (PF07005, IPR010737): Putative sugar-binding N-terminal domain
Sec20 (PF03908, IPR005606): Sec20
17 BPTFinteractor70.3818.619Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DDT (PF02791, IPR004022, SM00571): DDT domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GRP (PF07172, IPR010800): Glycine rich protein family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SDA1 (PF05285, IPR007949): SDA1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
18 C10orf2interactor100T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_25 (PF13481): AAA domain
19 CALCOCO2interactor140.38520.998bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
20 CALM1interactor200.28476.210EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
21 CAMK2Ainteractor60.6001.733CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
22 CASP8suppressor170.30056.934DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
23 CASP9oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
24 CAV1suppressor150.28649.668Caveolin (PF01146, IPR001612): Caveolin
25 CCNB1oncoprotein80.35711.517Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
26 CD44suppressor40.5001.833VP4_2 (PF08935, IPR015031): Viral protein VP4 subunit
Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
27 CD48interactor30.6671.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
28 CDC37protein found in more fusions200.27560.070CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
29 CDK1oncoprotein160.33338.477Pkinase (PF00069, IPR000719): Protein kinase domain
30 CDK9protein found in more fusions110.44414.121Pkinase (PF00069, IPR000719): Protein kinase domain
31 CEP135interactor110.32720.413DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPD52 (PF04201, IPR007327): Tumour protein D52 family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
32 CEP78interactor60.4671.424Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DUF3122 (PF11320, IPR021469): Protein of unknown function (DUF3122)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
33 CFTRsuppressor100.47212.832ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
34 CHAF1Ainteractor40.6670.400CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
35 CHDHinteractor21.0000GMC_oxred_C (PF05199, IPR007867): GMC oxidoreductase
GMC_oxred_N (PF00732, IPR000172): GMC oxidoreductase
36 CHMP2Bprotein found in more fusions31.0000Involucrin (PF00904, IPR000354): Involucrin repeat
Snf7 (PF03357, IPR005024): Snf7
37 CNTRLoncoprotein40.6671.333APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
38 CRHBPinteractor100CRF-BP (PF05428, IPR008435): Corticotropin-releasing factor binding protein (CRF-BP)
39 CSNK2A1oncoprotein260.31799.813Pkinase (PF00069, IPR000719): Protein kinase domain
40 CSNK2A2interactor120.39424.231Pkinase (PF00069, IPR000719): Protein kinase domain
41 CTNND1suppressor110.30918.756Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
42 CUL1suppressor270.36684.768Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
43 CUL2suppressor190.48032.225Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
44 CUL3protein found in more fusions480.201554.911Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
45 CUL7protein found in more fusions270.225132.036ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
46 CYLDsuppressor150.37139.955CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
47 DAZAP2protein found in more fusions80.4297.482DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
48 DCP2interactor40.5001.186DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
49 DIP2Binteractor21.0000AMP-binding (PF00501, IPR000873): AMP-binding enzyme
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
50 DNAI1interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
51 DNAI2interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
52 DVL2interactor150.30831.044DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
53 EDEM1interactor100Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
54 EEF1Dprotein found in more fusions130.40922.027EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
55 EGLN3suppressor90.35710.3712OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
56 EMILIN3interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EMI (PF07546, IPR011489): EMI domain
Erythro-docking (PF09277, IPR015357): Erythronolide synthase, docking
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
57 ENC1oncoprotein60.7001.150BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
HTH_12 (PF08461, IPR013668): Ribonuclease R winged-helix domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
58 ENPP1interactor21.0000Endonuclease_NS (PF01223, IPR001604, SM00892): DNA/RNA non-specific endonuclease
Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
59 EPAS1suppressor140.32132.109Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
60 EPDR1interactor100Ependymin (PF00811, IPR001299, SM00026): Ependymin
61 EPM2Ainteractor31.0000CBM_20 (PF00686, IPR002044): Starch binding domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
62 FASsuppressor90.39311.067Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
63 FHOD3interactor100Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
AAA_11 (PF13086): AAA domain
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
64 FKBP4interactor110.41813.669FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
65 FLNBoncoprotein120.33329.394CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
66 FUSsuppressor200.40560.524Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
67 GABARAPsuppressor230.33376.126Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
68 GABARAPL1interactor250.32377.150Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
69 GABARAPL2interactor240.33380.376Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
70 GAS6oncoprotein100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
71 GBASinteractor180.43839.140NIPSNAP (PF07978, IPR012577): NIPSNAP
72 GBP2interactor21.0000GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
73 GFM2interactor100EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
74 GLG1interactor30.6670.200BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat
75 GPC4interactor30.6670.667Glypican (PF01153, IPR001863): Glypican
76 GRIA1interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
77 GTF3C3interactor60.6671.212BUD22 (PF09073, IPR015158): BUD22
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
DUF3369 (PF11849, IPR021800): Domain of unknown function (DUF3369)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
TPR_20 (PF14561): Tetratricopeptide repeat
78 HADHAinteractor160.38331.4173HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
79 HADHBinteractor160.37527.660Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
80 HDAC6oncoprotein270.302119.882Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
81 HIF1Asuppressor160.38334.329Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
82 HNRNPA2B1oncoprotein180.49725.377RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
83 HSPA4interactor370.300198.146Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
84 HSPA5oncoprotein300.377115.556HSP70 (PF00012, IPR013126): Hsp70 protein
85 HSPB1oncoprotein330.296167.787HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
86 HTTprotein found in more fusions170.21754.460HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
87 IFI16suppressor110.29126.120HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
88 IKBKGinteractor320.202241.627CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
89 INAinteractor50.4001.030Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
90 INSRinteractor80.42912.408fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
91 IRAK1interactor230.32576.659Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
92 IRF8suppressor40.6670.500IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
93 ISG15suppressor100.46710.514ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
94 KEAP1oncoprotein270.200182.717BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
95 KIAA0753interactor70.4766.852MNR (PF15718, IPR031447): Protein moonraker
96 KIF5Binteractor80.3938.704ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
97 KLHL3interactor41.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
98 LCKoncoprotein130.22737.827Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
99 LDHAprotein found in more fusions110.44414.112Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
100 LGALS3oncoprotein60.5005.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
101 LIMD1suppressor60.4002.621LIM (PF00412, IPR001781, SM00132): LIM domain
102 LLGL1suppressor90.4727.676Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
103 LLGL2interactor80.3818.522Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
104 MALT1oncoprotein70.6671.243Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
105 MAP1LC3Ainteractor310.189222.142Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
106 MAP1LC3Binteractor220.33860.489Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
107 MAP1LC3Cinteractor110.5097.202Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
108 MAP2K5oncoprotein70.6002.041PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
109 MAP3K3oncoprotein130.31824.736PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
110 MAPK1oncoprotein250.232144.882Pkinase (PF00069, IPR000719): Protein kinase domain
111 MAPK13oncoprotein30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
112 MAPK14oncoprotein90.5007.602Pkinase (PF00069, IPR000719): Protein kinase domain
113 MAPTprotein found in more fusions190.35357.662Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
114 MBPinteractor110.21830.857Myelin_MBP (PF01669, IPR000548): Myelin basic protein
115 MED4interactor160.24262.882Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
116 MEIS2protein found in more fusions200Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
117 MLH1suppressor60.4673.349DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
118 MLST8interactor90.5286.174Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
119 MOV10interactor310.232165.963AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
120 MRPL38interactor50.9000.095PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095)
121 MTORoncoprotein240.281106.814DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
122 MYConcoprotein350.193258.346HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
123 MYD88oncoprotein80.5713.355Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
124 NBR1oncoprotein170.25061.557CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
125 NCOR1oncoprotein140.35232.042BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
126 NDUFA5interactor50.6002.476ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
127 NDUFS2interactor90.6392.413Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
128 NDUFS3protein found in more fusions150.46222.099Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
129 NEFMinteractor21.0000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
130 NFE2L2oncoprotein100.44415.173bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
131 NGFRsuppressor60.7001.733LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit
132 NIPSNAP1interactor160.45820.777NIPSNAP (PF07978, IPR012577): NIPSNAP
133 NOD2interactor70.9330.250CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
134 NPM1suppressor380.285250.137Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
135 NSUN4interactor100DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
RSRP (PF17069): Arginine/Serine-Rich protein 1
136 NTRK1oncoprotein680.1331329.596I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
137 NTRK2oncoprotein40.5001.833I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
138 NTRK3suppressor31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
139 NXF1interactor450.184434.154NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
140 OPTNprotein found in more fusions180.28746.439ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
141 OSBPL8interactor40.5001.175CDC45 (PF02724, IPR003874): CDC45-like protein
DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
142 PAN2interactor160.25053.519RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
143 PARK2suppressor370.200285.707IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
144 PARP10interactor40.8330.111PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
145 PAWRsuppressor40.6671.167ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
146 PCK1interactor70.6193.468PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
147 PDE4Aoncoprotein100NadA (PF02445, IPR003473): Quinolinate synthetase A protein
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
148 PEX5interactor40.6670.236TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
149 PIK3CAoncoprotein60.6672.952PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
150 PIK3R1oncoprotein120.32726.975RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
151 PIK3R2oncoprotein80.6074.643RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
152 PMLsuppressor230.29489.569zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
153 PPHLN1interactor50.7001.236Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
154 PRKCDsuppressor130.43917.805Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
155 PRKCIinteractor200.28980.402PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
156 PRKCZinteractor160.27653.495PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
157 PSMC2protein found in more fusions220.40052.640AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
158 PSMD10interactor110.5828.266Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
159 PSMD12interactor180.47128.737Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
160 PSMD3interactor150.44818.137Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
161 PSMD4interactor210.39562.497UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
162 PYCARDsuppressor50.6671.667CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
163 RAD23Aoncoprotein140.50017.610UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
164 RAD54L2interactor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
165 RARAoncoprotein100.38914.071zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
166 RBM45interactor70.6003.900RNA_bind (PF08675, IPR014789): RNA binding domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
167 RCN2interactor100.37812.026EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
168 RELNinteractor200BNR (PF02012, IPR002860): BNR/Asp-box repeat
EB (PF01683, IPR006149): EB module
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
Reeler (PF02014, IPR002861): Reeler domain
169 RIPK1protein found in more fusions140.35934.535Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
170 RPL37interactor31.0000Ribosomal_L37e (PF01907, IPR001569): Ribosomal protein L37e
171 RPS6KB1interactor90.4296.790Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
172 RPTORprotein found in more fusions210.33267.251HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
173 RRAGBinteractor50.8001.333Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
174 RRAGCinteractor60.7332.833Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
175 SASS6interactor50.7000.889CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
SAS-6_N (PF16531, IPR032396): Centriolar protein SAS N-terminal
176 SCCPDHinteractor21.0000Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
177 SDHAsuppressor100.7332.819FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
178 SESN1interactor30.6670.167PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
179 SESN2interactor30.6670.250PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
180 SKIoncoprotein120.38217.540c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
181 SMAD3oncoprotein200.28782.765MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
182 SNCAinteractor190.32751.311Synuclein (PF01387, IPR001058): Synuclein
183 SPRED2interactor21.0000Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
WH1 (PF00568, IPR000697, SM00461): WH1 domain
184 SRRM2interactor110.6185.621cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
185 STAT5Asuppressor50.6671.400SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
186 STUB1suppressor290.291147.187U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
187 STXBP1interactor30.6670.182Sec1 (PF00995, IPR001619): Sec1 family
188 SYNPO2suppressor50.6000.919Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
189 TARDBPinteractor210.44253.097RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
190 TBK1interactor160.28644.652DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
191 TGM2protein found in more fusions80.4294.756Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
192 TKTprotein found in more fusions110.51111.483Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
193 TMEM17interactor120.22734.886Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
194 TNFRSF10Asuppressor40.6671.167Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMIE (PF16038, IPR032006): TMIE protein
195 TNK2interactor90.28614.764CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
196 TOLLIPinteractor120.36421.287C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
197 TP53suppressor440.196437.834DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
198 TP53INP1suppressor50.5001.269DOR (PF14839, IPR029431): DOR family
199 TRAF1oncoprotein100.50011.686HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
200 TRAF6protein found in more fusions380.164385.955SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
201 TRIB3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
202 TRIM13suppressor50.5001.952ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
203 TRIM21interactor180.30957.757DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
204 TRIM5interactor70.6001.747Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0)
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
205 TRIM50interactor30.6670.500Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
SPRY (PF00622, IPR003877, SM00449): SPRY domain
Trm112p (PF03966, IPR005651): Trm112p-like protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
206 TRIM55interactor60.6003.333Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
207 TRIM63interactor60.6002.500DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
208 TRMT61Binteractor100GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit
209 TTNinteractor100.37818.946DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
210 TUBA1Aoncoprotein170.30144.977Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
211 TXNL1interactor100.7333.482PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
212 UBCprotein found in more fusions600.186856.400ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
213 UBXN1interactor100.7222.711Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
214 ULK1protein found in more fusions180.32458.824Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
215 ULK2interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
216 WDFY3interactor100.4008.422Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
217 XPO1interactor440.140583.737CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
218 YWHAZprotein found in more fusions330.244224.59314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
219 ZFAND5interactor41.0000zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
FAM53 (PF15242, IPR029356): Family of FAM53

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GEMIN4interactorNA
2 LINC00341interactorNA
3 SQSTM1parental proteinPB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain

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